BREAKING UP IS HARD TO DO

The U.S. Constitution was ratified based upon a contingency.  Some states agreed to ratify it only if a Bill of Rights was added, which professed to the world, and legally guaranteed U.S. citizens, certain inalienable rights.

Couldn't we then assume that if the federal government altered, amended, or abolished any of those inalienable rights, that the very ratification of the Constitution itself would be void?... or maybe that's the endgame (for some).